Effect of topical rebamipide on human conjunctival goblet cells.

to be associatedwith HPV 16. Higher-weight cytokeratins are encountered in the epidermis as opposed to mucous membranes.2,3 The 2 major differential diagnoses were sebaceous and mucoepidermoid carcinomas.4 Sebaceous carcinomawasexcludedbyoil redOcytoplasmicnegativityand immunohistochemical stains that demonstrated negativity for both adipophilin (except for faint focal positivity in necrotic zones) and androgen receptors.5,6 Sebaceous carcinomas are 100%positive for androgen receptors.6Mucoepidermoid carcinoma was excluded by negative Alcian blue and mucicarmine stains.4 Cutaneous squamous cell carcinomasof epidermal origin are 100% androgen receptor negative, but conjunctival dysplasias may rarely be focally positive.6 Immunohistochemistry can therefore be helpful in distinguishing clear-cell squamous carcinoma from sebaceous cell carcinoma.Our findings shouldalsohelp to resolve thecontroversy over whether sebaceous carcinoma can arise primarily in the conjunctival epithelium. Previous reports of this entity may in fact have been examples of clear-cell squamous carcinomas in situ. Accurate early diagnosis separating intraepithelial clear-cell squamous and sebaceous carcinomas should lead to improved clinical management of these disparate conditions.